The aim of this article is to select material for the components of the quadrotor drones with a time-variable structure. Although the use of a time-variable structure provides the capability to maneuver along various paths and exhibit diverse functionalities, dimensional changes may lead to component failures due to loads, vertical forces, and drag forces from the motors. Therefore, in the design process, in addition to considering weight and cost, parameters related to the durability and load-bearing capacity of the robot's structure must be examined. There are various criteria for selecting suitable materials for construction, and in this regard, the effectiveness of each criterion is specified in the design tables. Ultimately, the optimal materials for use are identified. The results indicate that by selecting Aluminum 7075-T6 and ABS+ Filament materials, the deformation of the drone's body under maximum motor loads is minimal, and the factors of weight and total cost are also optimized.